painting of sailboat abstract

Videos » Easy painting tutorial for beginners Abstract Sailboats Sunset ☀️🚢

Easy painting tutorial for beginners Abstract  Sailboats Sunset ☀️🚢

Sailboats At Sunset Beginners ACRYLIC Tutorial YOU CAN PAINT 🚢 Abstract can be easy with The Art Sherpa Step by step Classes

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painting of sailboat abstract

Modern abstract paintings by Osnat Tzadok

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Modern Abstract Seascape Paintings Sailboat Art on Canvas

  • Canvas Prints

Seascape painting - Day 1

What are Sailboat and Seascape Paintings

Ahoy there, mateys! If you're looking to add some nautical flair to your home decor, why not consider seascape paintings? And if you're feeling particularly adventurous, why not try an abstract style? After all, who needs a realistic depiction of a boat when you can have a colorful, whimsical interpretation?

Abstract sailboat paintings are the perfect way to add some personality to your walls. With their bold colors and unique shapes, they're sure to make a statement. Plus, they're a great conversation starter - who wouldn't want to chat about the meaning behind your abstract artwork? Maybe it's a representation of the freedom of the open sea, or maybe it's just a fun, funky design. Either way, it's sure to bring a smile to your face every time you look at it.

Of course, this type of abstract painting isn't for everyone. If you prefer a more traditional look, a seascape might be more your style. But don't worry, you can still have some fun with it! Instead of a boring, realistic depiction of the ocean, why not try a seascape with a twist? Maybe the waves are made of glitter, or the sky is a bright shade of purple. The possibilities are endless!

One of the best things about sailboat and seascape paintings is that they can work in any room of your house. Hang one in your living room to add some color and personality, or put one in your bedroom for a calming, beachy vibe. And if you're feeling really daring, why not put one in your bathroom? It's the perfect way to create a spa-like atmosphere and make your daily shower feel like a luxurious ocean escape.

So, whether you're a fan of abstract art or prefer a more traditional look, sailboat paintings and seascapes are a great way to add some nautical flair to your home decor. And with so many different styles and designs to choose from, there's sure to be something that fits your personality and style. So hoist the sails, set a course for home decor greatness, and let your imagination run wild!

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Love the sea no. 5822 black + white + copper thumb

Love the sea no. 5822 black + white + copper

Paintings ,  59.1 W x 39.4 H x 1.6 D in

Anita Kaufmann

Sailboats thumb

Paintings ,  5.1 W x 7.1 H x 0.4 D in

Konrad Biro

Prints from $90

Contre vent et marée... | « AGAINST WIND AND LOW TIDE... » thumb

Contre vent et marée... | « AGAINST WIND AND LOW TIDE... »

Paintings ,  47.2 W x 15.7 H x 0.8 D in

Olivier Messas

Ciel d’ivresse... | “HAPPY SKY...” (2019) thumb

Ciel d’ivresse... | “HAPPY SKY...” (2019)

Paintings ,  47.2 W x 47.2 H x 0.8 D in

Passion en mer... "PASSION AT SEA..." (SAILING SPIRIT 2022) thumb

Passion en mer... "PASSION AT SEA..." (SAILING SPIRIT 2022)

Paintings ,  31.5 W x 31.5 H x 0.8 D in

À l'infini... "TO INFINITY..." (SAILING SPIRIT 2023) thumb

À l'infini... "TO INFINITY..." (SAILING SPIRIT 2023)

Paintings ,  78.7 W x 23.6 H x 0.8 D in

Couleurs en mer... "COLORS AT SEA" (SAILING SPIRIT 2022) thumb

Couleurs en mer... "COLORS AT SEA" (SAILING SPIRIT 2022)

Paintings ,  39.4 W x 39.4 H x 0.8 D in

Les voiles de Saint-Tropez thumb

Les voiles de Saint-Tropez

Paintings ,  55.1 W x 55.1 H x 0.8 D in

sailboats thumb

Paintings ,  26.4 W x 33.9 H x 0 D in

OSCAR ALVAREZ

Prints from $100

Coucher de soleil sur les voiles... "SUNSET ON THE SAILS..." thumb

Coucher de soleil sur les voiles... "SUNSET ON THE SAILS..."

Au rythme des voiles blanches | “THE RHYTHM OF THE WHITE SAILS” thumb

Au rythme des voiles blanches | “THE RHYTHM OF THE WHITE SAILS”

Paintings ,  47.2 W x 19.7 H x 0.8 D in

Sailing away thumb

Sailing away

Paintings ,  23.6 W x 19.7 H x 0.8 D in

Elena Ivanova

Prints from $240

Couleurs de voiles... "COLORS OF SAILS" (2023) thumb

Couleurs de voiles... "COLORS OF SAILS" (2023)

Paintings ,  39.4 W x 23.6 H x 0.8 D in

Seashore thumb

Paintings ,  39.5 W x 28.5 H x 0.8 D in

Karen Darbinyan

Prints from $40

Couleurs à l'horizon... "COLORS AT THE HORIZON..." thumb

Couleurs à l'horizon... "COLORS AT THE HORIZON..."

Jeux de reflet... | « REFLECTION GAMES... » (2017) thumb

Jeux de reflet... | « REFLECTION GAMES... » (2017)

Le temps d'un coucher de soleil... "WHEN THE SUN GOES DOWN..." thumb

Le temps d'un coucher de soleil... "WHEN THE SUN GOES DOWN..."

Aux premières lueurs de l’aube... "DAWN" (2023) thumb

Aux premières lueurs de l’aube... "DAWN" (2023)

Paintings ,  23.6 W x 23.6 H x 0.8 D in

Été indien... | "INDIAN SUMMER..." thumb

Été indien... | "INDIAN SUMMER..."

Régate à l'horizon... | "RACE AT THE HORIZON..." thumb

Régate à l'horizon... | "RACE AT THE HORIZON..."

Paintings ,  70.9 W x 19.7 H x 0.8 D in

White Sails (North Sea Regatta) (Featured) thumb

White Sails (North Sea Regatta) (Featured)

Paintings ,  27.6 W x 27.6 H x 0.8 D in

Nelly van Nieuwenhuijzen

Prints from $69

Les voiliers de l’aurore... | “THE SAILBOATS OF THE DAWN..." thumb

Les voiliers de l’aurore... | “THE SAILBOATS OF THE DAWN..."

Un air de printemps... | "AN AIR OF SPRING..." thumb

Un air de printemps... | "AN AIR OF SPRING..."

Paintings ,  51.2 W x 15.7 H x 0.8 D in

Romance... "ROMANCE..." | SAILING SPIRIT 2022 thumb

Romance... "ROMANCE..." | SAILING SPIRIT 2022

Horizon d’été... | « SUMMER HORIZON... » thumb

Horizon d’été... | « SUMMER HORIZON... »

the race thumb

Paintings ,  39.4 W x 19.7 H x 1.6 D in

Martina Niederhauser-Landtwing

Prints from $59

Les mâts de l’horizon... | "MASTS AT THE HORIZON..." thumb

Les mâts de l’horizon... | "MASTS AT THE HORIZON..."

Paintings ,  19.7 W x 39.4 H x 0.8 D in

Jour de régate... | "RACING DAY..." (2019) thumb

Jour de régate... | "RACING DAY..." (2019)

Jeux de reflets... "REFLECTIONS" (SAILING SPIRIT 2021) thumb

Jeux de reflets... "REFLECTIONS" (SAILING SPIRIT 2021)

dream higher than the sky thumb

dream higher than the sky

Paintings ,  47.2 W x 13.8 H x 1.6 D in

Aux premières lueurs du jour... | "AT SUNRISE..." thumb

Aux premières lueurs du jour... | "AT SUNRISE..."

Le calme en mer... | "THE QUIET SEA..." thumb

Le calme en mer... | "THE QUIET SEA..."

Paintings ,  31.5 W x 31.5 H x 0.4 D in

Silence en mer... | "SILENCE AT SEA..." thumb

Silence en mer... | "SILENCE AT SEA..."

Paintings ,  68.9 W x 23.6 H x 0.8 D in

Jeux de lumière et de reflet... | "LIGHT AND REFLECTION..." thumb

Jeux de lumière et de reflet... | "LIGHT AND REFLECTION..."

the pink sky (symphony series) thumb

the pink sky (symphony series)

Paintings ,  39.4 W x 9.8 H x 1.6 D in

Liberté... "FREEDOM..." (2024) thumb

Liberté... "FREEDOM..." (2024)

Prints from $53

Espoir à l'horizon... "HOPE AT THE HORIZON..." (2023) thumb

Espoir à l'horizon... "HOPE AT THE HORIZON..." (2023)

À l’infini... | “INFINITY...” thumb

À l’infini... | “INFINITY...”

Paintings ,  59.1 W x 11.8 H x 0.8 D in

Voile en Bretagne... « SAILING IN BRETTES ANY..." thumb

Voile en Bretagne... « SAILING IN BRETTES ANY..."

Coming back at Sunset thumb

Coming back at Sunset

Paintings ,  11 W x 15 H x 2 D in

Armando Chiarino

Sailing Winds - 4 thumb

Sailing Winds - 4

Paintings ,  60 W x 60 H x 1.8 D in

Sumati Sharma

Prints from $50

Aurore... "DAWN..."  | 40x120x2cm thumb

Aurore... "DAWN..." | 40x120x2cm

Landscape with a Sail Boat thumb

Landscape with a Sail Boat

Paintings ,  3.8 W x 5.1 H x 0.1 D in

Vita Schagen

Sailing With The League thumb

Sailing With The League

Paintings ,  18 W x 24 H x 1.6 D in

Sophia Oshodin

Morning in the Harbor thumb

Morning in the Harbor

Paintings ,  48 W x 48 H x 2 D in

Alma Ramirez

Les couleurs du printemps... | "THE COLORS OF SPRING... » (2019) thumb

Les couleurs du printemps... | "THE COLORS OF SPRING... » (2019)

Harbor Life thumb

Harbor Life

Paintings ,  23.6 W x 31.5 H x 1.2 D in

Jelena Djokic

Prints from $84

Horizon d'éternité... "HORIZON OF ETERNITY" (2022) thumb

Horizon d'éternité... "HORIZON OF ETERNITY" (2022)

Eastern Scheldt Regatta (July) thumb

Eastern Scheldt Regatta (July)

Paintings ,  35.4 W x 35.4 H x 0.8 D in

Prints from $61

Blue lakescape thumb

Blue lakescape

Paintings ,  11.8 W x 9.4 H x 0.8 D in

Atelier BDGB

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Abstract Sailboat royalty-free images

43,212 abstract sailboat stock photos, vectors, and illustrations are available royalty-free for download., colorful oil painting on canvas texture. impressionism image of seascape paintings with sunlight background. modern art oil paintings with boat, sail on sea. abstract contemporary art for background.

Colorful oil painting on canvas texture. Impressionism image of seascape paintings with sunlight background. Modern art oil paintings with boat, sail on sea. Abstract contemporary art for background Stock Illustration

Nautical logos and icons

Nautical logos and icons Stock Vector

Aerial view of sailboat mooring in the sea and two sailors watching sunrise near Mons Klint, Denmark.

Aerial view of sailboat mooring in the sea and two sailors watching sunrise near Mons Klint, Denmark. Stock Photo

Sail of a sailing boat against sky

Sail of a sailing boat against sky Stock Photo

Oil Painting - Sailing Boat

Oil Painting - Sailing Boat Stock Illustration

Wave, surf and flow icons

Wave, surf and flow icons Stock Vector

Polygonal Sailing yacht. Sea business concept. Vector Sailboat mesh spheres from flying debris. Thin line concept. Blue structure style illustration

Polygonal Sailing yacht. Sea business concept. Vector Sailboat mesh spheres from flying debris. Thin line concept. Blue structure style illustration Stock Vector

Seamless abstract sea background. Sailboats on a waves. Vector wavy striped pattern.

Seamless abstract sea background. Sailboats on a waves. Vector wavy striped pattern. Stock Vector

Beautiful botanical vector seamless pattern background with coconut palm trees, sailboat silhouettes, sun, mountaines. Isolated on white background. The Summer beach surfing illustration.

Beautiful botanical vector seamless pattern background with coconut palm trees, sailboat silhouettes, sun, mountaines. Isolated on white background. The Summer beach surfing illustration.  Stock Vector

Sails and mast in the blue sky

Sails and mast in the blue sky Stock Photo

Yacht vector logo templates. Yachts silhouettes. Vector line yachts icon, vector illustration. Yachting and regatta symbols

Yacht vector logo templates. Yachts silhouettes. Vector line yachts icon,  vector illustration. Yachting and regatta symbols Stock Vector

set of sailboat icons, vector illustration

set of sailboat icons, vector illustration Stock Vector

Marine seamless pattern with cartoon boats on blue background

Marine seamless pattern with cartoon boats on blue background Stock Vector

vector sign for sailing

vector sign for sailing Stock Vector

Set of nautical icons. Yachts and sailboats. Vol 1.

Set of  nautical  icons. Yachts and sailboats. Vol 1. Stock Vector

Little Girl sitting on the open books.She looks at sailing boat and migrating birds over the mountains.Childhood dreams, creature and education concept.Wondering world.Textured paper abstract collage

Little Girl sitting on the open books.She looks at sailing boat and migrating birds over the mountains.Childhood dreams, creature and education concept.Wondering world.Textured paper abstract collage Stock Photo

Beautiful tropical vector seamless pattern background with coconut palm trees, sailboat silhouettes, sun, mountaines, whale tails. Isolated on white background. The Summer beach surfing illustration

Beautiful tropical vector seamless pattern background with coconut palm trees, sailboat silhouettes, sun, mountaines, whale tails.  Isolated on white background. The Summer beach surfing illustration Stock Vector

The logo on the theme of the summer and Tourism

The logo on the theme of the summer and Tourism Stock Vector

Journey of the paper sailboat in the winding blue sea, Paper art and digital craft style background, Vector illustration

Journey of the paper sailboat in the winding blue sea, Paper art and digital craft style background, Vector illustration Stock Vector

Vector seamless pattern with sea elements: lighthouses, ships, anchors. Can be used for wallpapers, web page backgrounds.

Vector seamless pattern with sea elements: lighthouses, ships, anchors. Can be used for wallpapers, web page backgrounds. Stock Vector

Illustration Summer beach and palm trees on the background of the sea and white sailboat

Illustration Summer beach and palm trees on the background of the sea and white sailboat Stock Vector

abstract colorful seamless backgrounds

abstract colorful seamless backgrounds Stock Vector

Origami paper ship and sailboat sailing

Origami paper ship and sailboat sailing Stock Vector

Seamless pattern with cute color ships

Seamless pattern with cute color ships Stock Vector

Vector abstract seamless pattern on the theme of travel, adventure and discovery. Vintage repeatable background with hand-drawn sailboats, map, wind rose, anchors, sketches, inscriptions and ink blots

Vector abstract seamless pattern on the theme of travel, adventure and discovery. Vintage repeatable background with hand-drawn sailboats, map, wind rose, anchors, sketches, inscriptions and ink blots Stock Vector

Sailboat composed of polygon. Logo concept. Low poly vector illustration of a mesh . The ship consists of lines, dots and shapes. Wireframe connection structure

Sailboat composed of polygon. Logo concept. Low poly vector illustration of a mesh . The ship consists of lines, dots and shapes. Wireframe connection structure Stock Vector

Sailboats surrounded by stripes and graphic motifs

Sailboats surrounded by stripes and graphic motifs Stock Illustration

Seamless pattern with sailboat, anchor, steering wheel and lifebuoy. Cute Marine pattern for fabric, baby clothes, background, textile, wrapping paper and other decoration.Vector illustration.

Seamless pattern with sailboat, anchor, steering wheel and lifebuoy. Cute Marine pattern for fabric, baby clothes, background, textile, wrapping paper and other decoration.Vector illustration. Stock Vector

Sailing logo

Sailing logo Stock Vector

vintage background with a sailboat

vintage background with a sailboat Stock Illustration

Abstract mash line and point Sailing yacht on white background with an inscription. Starry sky or space, consisting of stars and the universe. Vector Sailboat business illustration

Abstract mash line and point Sailing yacht on white background with an inscription. Starry sky or space, consisting of stars and the universe. Vector Sailboat business illustration Stock Vector

Sailing poster design template. Abstract background with sailboat, sea and sunset.

Sailing poster design template. Abstract background with sailboat, sea and sunset. Stock Vector

three red sails against the sky and the sea and the coming sun drawn by oil color on canvas

three red sails against the sky and the sea and the coming sun drawn by oil color on canvas Stock Illustration

Beautiful botanical vector seamless pattern background with the ocean, sailboat silhouettes. Isolated on white background. The Summer beach surfing illustration.

Beautiful botanical vector seamless pattern background with the  ocean,  sailboat silhouettes. Isolated on white background. The Summer beach surfing illustration. Stock Vector

Winch with rope on sailing boat in the sea

Winch with rope on sailing boat in the sea Stock Photo

Sailing yacht on the sea waves. Sailboat. Vector drawn flat illustration. Isolated on white background.

Sailing yacht on the sea waves. Sailboat. Vector drawn flat illustration. Isolated on white background. Stock Vector

boat logo template

boat logo template Stock Vector

Vector abstract seamless background on the theme of travel, adventure and discovery. Old manuscript with caravels, wind rose, anchors and other nautical symbols with blots and stains in vintage style

Vector abstract seamless background on the theme of travel, adventure and discovery. Old manuscript with caravels, wind rose, anchors and other nautical symbols with blots and stains in vintage style Stock Vector

Digital painting of boat in the ocean at sunset. Rastr stock llustration

Digital painting of  boat in the ocean at sunset. Rastr stock llustration Stock Illustration

Sail over blue clear sky, abstract background, active lifestyle, detail of sailboat, luxury water transport, bright sun light, summer holidays concept

Sail over blue clear sky, abstract background, active lifestyle, detail of sailboat, luxury water transport, bright sun light, summer holidays concept Stock Photo

Paper cut sail boat over sea wave vector. 3d craft art design. Travel background. Water cruise illustration. Nautical voyage, tour on yacht during vacation time advertisement

Paper cut sail boat over sea wave vector. 3d craft art design. Travel background. Water cruise illustration. Nautical voyage, tour on yacht during vacation time advertisement Stock Vector

Sea Graphics Series - Sailing Ship and Sun

Sea Graphics Series - Sailing Ship and Sun Stock Vector

yacht sails

yacht sails Stock Photo

Vector abstract seamless background on the theme of travel, adventure and discovery. Old hand drawn map with vintage sailing yachts, wind rose, routs, nautical symbols and handwritten inscriptions

Vector abstract seamless background on the theme of travel, adventure and discovery. Old hand drawn map with vintage sailing yachts, wind rose, routs, nautical symbols and handwritten inscriptions Stock Vector

Ship Wheel. Polygonal abstract travel or business illustration. Low poly blue vector illustration of a starry sky or Cosmos. Vector image in RGB Color mode. Leadership concept

Ship Wheel. Polygonal abstract travel or business illustration. Low poly blue vector illustration of a starry sky or Cosmos. Vector image in RGB Color mode. Leadership concept Stock Vector

continuous line drawing of sailboat

continuous line drawing of sailboat Stock Vector

Abstract paper art of summer sea scenery with sea water splashing and beach equipment on beach. Sea landscape. Summer time. Paper cut and craft style. vector, illustration.

Abstract paper art of summer sea scenery with sea water splashing and beach equipment on beach. Sea landscape. Summer time. Paper cut and craft style. vector, illustration. Stock Vector

Original oil painting of lighthouse and storm in ocean on canvas.Modern Impressionism

Original oil painting of  lighthouse and storm in ocean on canvas.Modern Impressionism Stock Illustration

blue Sailing boat logo set. icon abstract vector template. Sailboat on the waves. Vector illustration

blue Sailing boat logo set. icon abstract vector template. Sailboat on the waves. Vector illustration Stock Vector

Oil painting on canvas. Sunset over the sea and sailboat. Modern art

Oil painting on canvas. Sunset over the sea and sailboat. Modern art Stock Illustration

Seamless pattern with nautical elements

Seamless pattern with nautical elements Stock Vector

Sea wave and ship vector illustration

Sea wave and ship vector illustration Stock Vector

abstract vector background with copy space for your text

abstract vector background with copy space for your text Stock Vector

Motor boats catamaran windsurfer and sailboat various types of water transport flat icons set abstract isolated vector illustration

Motor boats catamaran windsurfer and sailboat various types of water transport flat icons set abstract isolated vector illustration Stock Vector

Beautiful botanical vector seamless pattern background with coconut palm trees, sailboat silhouettes. Isolated on white background. The Summer beach surfing illustration.

Beautiful botanical vector seamless pattern background with coconut palm trees, sailboat silhouettes. Isolated on white background. The Summer beach surfing illustration. Stock Vector

Beautiful botanical vector seamless pattern background with coconut palm trees, topical plants, sailboat silhouettes, sun. Isolated on white background. The Summer beach surfing illustration.

Beautiful botanical vector seamless pattern background with coconut palm trees, topical plants, sailboat silhouettes, sun. Isolated on white background. The Summer beach surfing illustration.  Stock Vector

sailboater's equipment on yacht

sailboater's equipment on yacht Stock Photo

Retro Border with Sailing Ships. Seamless hand drawn Pattern

Retro Border with Sailing Ships. Seamless hand drawn Pattern Stock Vector

Vector black sailboat icons set on white background

Vector black sailboat icons set on white background Stock Vector

huge sailing boat at sea

huge sailing boat at sea Stock Photo

Vector blue watercolor sailboats. Sailing regatta

Vector blue watercolor sailboats. Sailing regatta Stock Vector

Businessman Leader looking through a telescope by two business people stands with a paddle floating on a paper boat on the sea. illustration Vector

Businessman Leader looking through a telescope by two business people stands with a paddle floating on a paper boat on the sea.  illustration Vector Stock Vector

Abstract watercolor boat, red flag, floating on the waves of the ocean - a template for the invitation cards, concept of love and freedom - texture of paint paper in blue color - vector illustration

Abstract watercolor boat, red flag, floating on the waves of the ocean - a template for the invitation cards, concept of love and freedom - texture of paint paper in blue color - vector illustration Stock Vector

Two sailboats on peaceful still waters in a harbor.

Two sailboats on peaceful still waters in a harbor. Stock Photo

Paper art of Sailing boat floating and cut a paper at the same time, Journey and travel concept, Vector illustration

Paper art of Sailing boat floating and cut a paper at the same time, Journey and travel concept, Vector illustration Stock Vector

ship steering wheel vintage vector illustration

ship steering wheel vintage vector illustration Stock Vector

Abstract colorful oil painting landscape on canvas. Semi- abstract image of white sailboat and green hill, blue lake with sunlight and sky. Spring season nature background

Abstract colorful oil painting landscape on canvas. Semi- abstract image of white sailboat and green hill, blue lake with sunlight and sky. Spring season nature background Stock Illustration

origami boat sailing in blue ocean , paper art style

origami boat sailing in blue ocean , paper art style Stock Vector

marine zigzag seamless pattern

marine zigzag seamless pattern Stock Vector

solid icons set, transportation, Boat and shadow, vector illustrations

solid icons set, transportation, Boat and shadow, vector illustrations Stock Vector

VECTOR origami paper boat

VECTOR origami paper boat Stock Vector

illustration of isolated a sailboat gliding on white

illustration of isolated a sailboat gliding on white Stock Vector

Pair it is yellow white sails against the sky and the sea and the coming sun drawn on water color kraft paper water color colors

Pair it is yellow white sails against the sky and the sea and the coming sun drawn on water color kraft paper water color colors Stock Photo

Sailboat line art. Logo concept. Scetch stile vector illustration. The ship consists of lines, dots and shapes. Wireframe connection structure

Sailboat line art. Logo concept. Scetch stile vector illustration. The ship consists of lines, dots and shapes. Wireframe connection structure Stock Vector

Abstract linear diadem logotype. Ship shell vector logo.

Abstract linear diadem logotype. Ship shell vector logo. Stock Vector

Set of black and white graphic yacht club, sailing sport logo templates, vector illustration isolated on white background. Graphic yacht, sail boat logotype, logo design

Set of black and white graphic yacht club, sailing sport logo templates, vector illustration isolated on white background. Graphic yacht, sail boat logotype, logo design Stock Vector

Abstract blue sea and sky with sailboats sailing on copy space

Abstract blue sea and sky with sailboats sailing on copy space Stock Vector

Nautical icons

Nautical icons Stock Vector

Nautical background with paper boat

Nautical background with paper boat Stock Vector

isometric business people are floating on a paper boat on the sea, leader at the helm, another businessman stands with a paddle, a businesswoman looking through a telescope. business concept team

isometric business people are floating on a paper boat on the sea, leader at the helm, another businessman stands with a paddle, a businesswoman looking through a telescope. business concept team Stock Vector

Boat and sea wave icon

Boat and sea wave icon Stock Vector

Origami paper ship isolated on white background.

Origami paper ship isolated on white background. Stock Vector

Abstract summer seamless pattern. Watercolor sailboat, palm tree, leaves, grunge textures, doodles, brush strokes. Water color background in minimalistic style. Hand painted tropical illustration

Abstract summer seamless pattern. Watercolor sailboat, palm tree, leaves, grunge textures, doodles, brush strokes. Water color background in minimalistic style. Hand painted tropical illustration Stock Illustration

Surf club logo or emblem against stormy tropical seascape. Only free font used.

Surf club logo or emblem against stormy tropical seascape. Only free font used. Stock Vector

Little red sailboat cruising among floating icebergs in Disko Bay glacier during midnight sun season of polar summer. Ilulissat, Greenland.

Little red sailboat cruising among floating icebergs in Disko Bay glacier during midnight sun season of polar summer. Ilulissat, Greenland. Stock Photo

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painting of sailboat abstract

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Chemical Science

Protein painting for structural and binding sites analysis via intracellular lysine reactivity profiling with o-phthalaldehyde.

The three-dimensional structure and the molecular interaction of proteins determine their roles in many cellular processes. Chemical protein painting with protein mass spectrometry can identify changes in structural conformations and molecular interactions of proteins including their binding sites. Nevertheless, most current protein painting techniques identified protein targets and binding sites of drugs in vitro using cell lysate or purified protein. Here, we tested 11 membrane-permeable lysine-reactive chemical probes for intracellular covalent labeling of endogenous proteins, which reveals ortho-phthalaldehyde (OPA) as the most reactive probe in intracellular environment. An MS workflow and a new data analysis strategy termed RAPID (Reactive Amino acid Profiling by Inverse Detection) was developed to enhance detection sensitivity. RAPID with OPA successfully identified structural change induced by allosteric drug TEPP-46 on its target protein PKM2, and was applied to profile conformation change of the proteome occurring in cells during thermal denaturation. Application of RAPID-OPA on cells treated with geldanamycin, selumetinib, and staurosporine successfully revealed their binding sites on target proteins. Thus, RAPID-OPA for cellular protein painting permits the identification of ligand-binding sites and detection of protein structural changes occurring in cells.

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painting of sailboat abstract

Z. Zheng, Y. Zeng, K. Lai, B. Liao, P. Li and C. S. H. Tan, Chem. Sci. , 2024, Accepted Manuscript , DOI: 10.1039/D4SC00032C

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